Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.

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Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing low-density lipoprotein LDL receptors on hepatocytes. This article has been cited by other articles in PMC. The effect of particle size on the exckpients strength of tablets. The functionality of excipients means improvement in flow properties, compressibility, and better dilution potential.

Blend containing the drug along with the excipients was weighed and it was kept in an open cylinder which was placed on graph sheet. In the present study an attempt has been made to evaluate Ocimum bascilium mucilage coprocessed with Mannitol as a novel super disintegrant. The aim of this technique is to improve the flow properties of the used excipients when compared to those with the individual physical mixtures.

Again weight of powder was measured. Micromeritic properties of co-processing excipients formulated with different ratios of acacia mucilage and calcium carbonate. The granules of the formulations with excupients acacia F 1 and pure CaCO 3 F 2 showed passable flow properties. This blend was mixed well and was compressed in a rotary tablet machine using 5 mm punch die.

In the present study, we successfully developed directly compressed tablets with sufficient hardness although exhibiting rapid disintegration. The disintegration time was measured in 10 ml water by considering the small volume of saliva Figure 3. Disintegration time and in vitro drug release was done by in house method. Hence, this study involves both advantages of wet granulation and direct compression as atorvastatin calcium is very slightly soluble in water.


Co-processed Excipients

Like other statins, atorvastatin also reduces blood levels of triglycerides and slightly increases levels of high-density lipoprotein HDL -cholesterol. Different ratios along with its disintegration time have been depicted in Tables 3 and 4 respectively. To simulate the environment of oral cavity, a modified method was developed for the assessment of disintegration time and dissolution profile exccipients drug.

SSG which disintegrated within 11 sec at the concentration of 1 gm: After 30 days the samples were withdrawn and characterized for weight variation, hardness, disintegration time, drug content and in vitro drug release study.

To determine dissolution profile, same principle was used as in disintegration test that small volume of saliva.

Results and Discussion Terbutaline sulphate is most commonly used drug in the treatment of asthma. Gums and mucilage are most widely used as natural excipients in pharmaceutical manufacturing. To overcome these problems, the functionality of excipients can be improved by either developing new grades of excipients or modification of existing excipients.

Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation

The sample was poured through the funnel until the apex of the conical pile touched the tip of the funnel. It has excellent swelling index that is Atorvastatin calcium is a member of the drug class known as statins, used for lowering blood cholesterol. Keywords Mouth dissolving tablet; Terbutaline sulphate; Coprocessed excipient; Ocimum bascilium ; Superdisintegrant Introduction Oral solid dosage forms are most commonly preferred dosage form due to its ease of manufacturing, user friendly nature and capital interest also.

Mostly binding and blending properties are enhanced by this technique than the formulations involving the individual excipients. Atorvastatin calcium shows pH dependent solubility and is soluble in alkaline medium. Particle level comprises individual particle properties such as shape, size, surface area, and porosity that reflect in bulk level by improving functionality excipients [ 6 ].


The co-processed excipients were prepared by granulation technique. All the results of the post-compression tests were satisfactory and were within the pharmacopoeial limits.

A material to be used for direct compression process should possess an adequate level of flow ability when blending with other ingredients in formulation to ensure a uniform die filling of a powder coprocesxed during tableting.

For the friability, twenty undusted tablets were weighted, put in the friabilator Electrolab, EF-1W for cycles and re-weighted.

Usually most of the formulations have excipients in higher proportion than the drug. Coprocessed excipients were prepared by solvent evaporation method and evaluated in the formulation of mouth dissolving tablets of Terbutaline sulphate.

Co-processed Excipients

The properties are evaluated by Hausner’s ratio and Carr’s index values. All the pre-compression parameters were calculated for the co-processed excipient granules, granules of pure acacia and CaCO 3 in addition to the friability of granules.

It is calculated as. Both excipients should be in such a proportion that the formed blend shows good binding properties and good flow properties. The composition of the tablets was represented in Table 1. Suitable dilutions were made and analyzed spectrophotometrically by measuring the absorbance at nm.

Coprocessed excipient having good flow ability is an important requirement for a direct compression excipient. Evaluation of mouth dissolving tablets Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content.