What is an NSAID? Nonsteroidal Anti-inflammatory drug. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. This paper also provides. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs to decrease NSAID-induced GI damage including use of.

Author: Zulutilar Tygogar
Country: Zambia
Language: English (Spanish)
Genre: Photos
Published (Last): 1 September 2012
Pages: 127
PDF File Size: 18.80 Mb
ePub File Size: 16.7 Mb
ISBN: 857-1-39516-665-8
Downloads: 58823
Price: Free* [*Free Regsitration Required]
Uploader: Nikorg

Mitochondria, oxidative stress and cell death.

However, the fluorescence intensities gastropato cells pretreated with rebamipide were significantly reduced than those in cells treated with indomethacin alone: The surface epithelial cells are served as the second line of defense. Before issuing any prescription, three key questions should be considered: Introduction Nonsteroidal anti-inflammatory drugs NSAIDs are the most well recognized drugs worldwide for the treatment of pain, inflammation, and fever [ 1 — 4 ].

H2 receptor antagonists are effective in preventing duodenal ulcer but not gastric ulcer. Non-steroidal anti-inflammatory drugs NSAIDs such as aspirin and indomethacin are the most commonly prescribed drugs for arthritis, inflammation, and cardiovascular protection.

Non-steroidal anti-inflammatory drug gastropathy: causes and treatment.

Bellarmine Student Project Medical Pharmacology. In this paper, the mechanism of action of NSAIDs and their critical gastrointestinal complications have been reviewed. Gastrointest Endosc Clin Snaid Am.

Philipp Daumke Averbis GmbH. Several strategies have been adapted to control the critical side-effects. Proton pump inhibitor PPI omeprazole reduces gastric ulcer and prevents duodenal ulcer [2]. COX-1 is constitutively expressed and is responsible for the normal physiological protection of gastric mucosa. Role of gastric acid secretion in progression of acute gastric erosions induced by ischemia-reperfusion into gastric ulcers.


Other treatment options include misoprostol which is a synthetic prostaglandin designed to replace those loss by NSAIDs.

Mediators of Inflammation

Scand J Rheumatol Suppl. These drugs inhibit prostaglandin biosynthesis and produce their therapeutic effects tastropati 8 ]. ST88 Injury, poisoning and certain other consequences of external causes ST88 TT88 Injury, poisoning and certain other consequences of external causes TT88 TT50 Poisoning by, adverse effects of and underdosing nnsaid drugs, medicaments and biological substances TT50 T39 Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics T Radiography with barium can also detect and diagnose peptic ulcers but is less common than endoscopy.

Physiopedia is not a substitute for professional advice or expert medical services from a qualified healthcare provider.

In this regard, several prevention methods have been used. View at Google Scholar K. NSAIDs are commonly administered for treatment against inflammatory diseases, rheumatoid arthritis, osteoarthritis, dysmenorrhea, and ischemic cerebrovascular disorders [ 5 ].

Reductions in prescribing arising from a prior authorization scheme show that this can be achieved.

Prevention and Treatment of NSAID Gastropathy.

Mucous and bicarbonate are secreted by gastric epithelial cells. Cells were immunohistochemically stained with monoclonal antibodies for caspase 3 and caspase 9. It is suggested that NSAIDs cause membrane permeabilization leading to disruption of epithelial barrier [ 46 ]. Dual antiplatelet therapy with thienopyridine like clopidogrel and NSAID like aspirin is prescribed to decrease adverse cardiac events in patients suffering from acute coronary syndromes or placement of an intracoronary stent [ 7273 ], but they are associated with high risks of GI bleeding [ 21 ].


PGs play a key role in gastric epithelial defense by enhancing the pre-epithelial, epithelial, post-epithelial defense mechanisms: Free oxygen radicals react with poly unsaturated fatty acids of the mucosa leading to lipid peroxidation and tissue damage [ 54 ].

Control of activity states of heart mitochondrial ATPase. COX-1 is found gastroppati all tissues of the body whereas COX-2 is in the area of inflammation such as in an area of osteoarthritis contributing to the inflammation. The function of cyclooxygenase in this process led to the establishment of two COX isoforms: The role of intestinal permeability in NSAID-induced small intestinal injury is extensively examined by Bjarnason and colleagues.

In gastric juice, they are non-ionized and lipid soluble.